Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials.

Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials.

<h4>Background</h4>Mass administrations of antimalarial drugs (MDA) have reduced the incidence and prevalence of P. falciparum infections in a trial in the Greater Mekong Subregion. Here we assess the impact of the MDA on P. vivax infections.<h4>Methods</h4>Between May 2013 a...

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Main Authors: Koukeo Phommasone, Frank van Leth, Thomas J Peto, Jordi Landier, Thuy-Nhien Nguyen, Rupam Tripura, Tiengkham Pongvongsa, Khin Maung Lwin, Ladda Kajeechiwa, May Myo Thwin, Daniel M Parker, Jacher Wiladphaingern, Suphak Nosten, Stephane Proux, Chea Nguon, Chan Davoeung, Huy Rekol, Bipin Adhikari, Cholrawee Promnarate, Kesinee Chotivanich, Borimas Hanboonkunupakarn, Podjanee Jittmala, Phaik Yeong Cheah, Mehul Dhorda, Mallika Imwong, Mavuto Mukaka, Pimnara Peerawaranun, Sasithon Pukrittayakamee, Paul N Newton, Guy E Thwaites, Nicholas P J Day, Mayfong Mayxay, Tran Tinh Hien, Francois H Nosten, Frank Cobelens, Arjen M Dondorp, Nicholas J White, Lorenz von Seidlein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228190

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https://doi.org/10.1371/journal.pone.0228190

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