Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. Hypoxia-inducible factor-1α (HIF-1α) as a transcription factor in response to hypoxia suggests that it could be a potential therapeutic target for the treatment of RA. In this study, we assessed whether the HIF pathway blocka...

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Bibliographic Details
Main Authors: Yiping Hu, Tiantian Zhang, Jingqin Chen, WenXiang Cheng, Jianhai Chen, Zhengtan Zheng, Jietao Lin, Guoyuan Zhu, Yong Zhang, Xueling Bai, Yan Wang, Bing Song, Qingwen Wang, Ling Qin, Peng Zhang
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120300494

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http://www.sciencedirect.com/science/article/pii/S2162253120300494

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