Species Differences in Microsomal Metabolism of Xanthine-Derived A<sub>1</sub> Adenosine Receptor Ligands

Species Differences in Microsomal Metabolism of Xanthine-Derived A<sub>1</sub> Adenosine Receptor Ligands

Tracer development for positron emission tomography (PET) requires thorough evaluation of pharmacokinetics, metabolism, and dosimetry of candidate radioligands in preclinical animal studies. Since variations in pharmacokinetics and metabolism of a compound occur in different species, careful selecti...

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Bibliographic Details
Main Authors: Daniela Schneider, Dirk Bier, Marcus Holschbach, Andreas Bauer, Bernd Neumaier
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
A<sub>1</sub> adenosine receptor
liver microsomes
metabolism
radioligand
species differences
preclinical evaluation
Online Access:https://www.mdpi.com/1424-8247/14/3/277

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https://www.mdpi.com/1424-8247/14/3/277

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