Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

The role of glutamate N-methyl-D-Aspartate receptor (NMDAR) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders. Recently, it was demonstrated that astrocytic GLT-1 blockade leads to an anxiety-like phenotype. Although astrocytes are...

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Bibliographic Details
Main Authors: Eduardo R Zimmer, Vitor R Torrez, Eduardo eKalinine, Marina C Augustin, Kamila C Zenki, Roberto Farina Almeida, Gisele eHansel, Alexandre P Muller, Diogo O Souza, Rodrigo eMachado-Vieira, Luis V Portela
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Anxiety
Astrocytes
Behavior
Glutamates
Memantine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00219/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00219/full

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