Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype
The role of glutamate N-methyl-D-Aspartate receptor (NMDAR) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders. Recently, it was demonstrated that astrocytic GLT-1 blockade leads to an anxiety-like phenotype. Although astrocytes are...
Main Authors: | Eduardo R Zimmer, Vitor R Torrez, Eduardo eKalinine, Marina C Augustin, Kamila C Zenki, Roberto Farina Almeida, Gisele eHansel, Alexandre P Muller, Diogo O Souza, Rodrigo eMachado-Vieira, Luis V Portela |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-06-01
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Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00219/full |
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