Cytotoxicity and Pro-Apoptotic Activity of 2,2´-Bis[4,5-bis(4-hydroxybenzyl)-2-(4-hydroxyphenyl)cyclopent-4-en-1,3-dione], a Phenolic Cyclopentenedione Isolated from the Cyanobacterium Strain Nostoc sp. str. Lukešová 27/97

Cytotoxicity and Pro-Apoptotic Activity of 2,2´-Bis[4,5-bis(4-hydroxybenzyl)-2-(4-hydroxyphenyl)cyclopent-4-en-1,3-dione], a Phenolic Cyclopentenedione Isolated from the Cyanobacterium Strain Nostoc sp. str. Lukešová 27/97

The cytotoxicity of the polyphenol 2,2´-bis[4,5-bis(4-hydroxybenzyl)-2-(4-hydroxyphenyl)cyclopent-4-en-1,3-dione], nostotrebin 6 (NOS-6), was tested under in vitro conditions using mouse fibroblasts (BALB/c cells). Identification of NOS-6 and its uptake into fibroblasts was examined by multi-stage m...

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Bibliographic Details
Main Authors: Jan Vacek, Jan Hrbáč, Jiří Kopecký, Jitka Vostálová
Format: Article
Language:English
Published: MDPI AG 2011-05-01
Series:Molecules
Subjects:
polyphenol
cyclopentenediones
cytotoxicity
apoptosis
necrosis
Online Access:http://www.mdpi.com/1420-3049/16/5/4254/

Internet

http://www.mdpi.com/1420-3049/16/5/4254/

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