Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors

The range of chemicals detectable by cell-free systems is still limited. Here the authors combine metabolic cascades with transcription factor networks to detect small molecules in complex environments.

Bibliographic Details
Main Authors: Peter L. Voyvodic, Amir Pandi, Mathilde Koch, Ismael Conejero, Emmanuel Valjent, Philippe Courtet, Eric Renard, Jean-Loup Faulon, Jerome Bonnet
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09722-9