Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish

Neutrophils are fast-moving cells essential for host immune functions. Although they primarily rely on glycolysis for ATP, isolated primary human neutrophils depend on mitochondrial membrane potential for chemotaxis. However, it is not known whether mitochondria regulate neutrophil motility in vivo,...

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Bibliographic Details
Main Authors: Wenqing Zhou, Lingyan Cao, Jacob Jeffries, Xiaoguang Zhu, Christopher J. Staiger, Qing Deng
Format: Article
Language:English
Published: The Company of Biologists 2018-03-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/11/3/dmm033027