Human biodistribution and internal dosimetry of 4-[ 18 F]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart

Human biodistribution and internal dosimetry of 4-[ 18 F]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart

Abstract Background 4-[18F] fluorobenzyl dexetimide (F-DEX) is the first non-subtype selective fluorine-18 labelled tracer for muscarinic receptors (mAChR) used in humans. A recent first-in-human study found high regional brain uptake with low variation in normal subjects. Disturbance of mAChR has b...

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Bibliographic Details
Main Authors: Cameron D. Pain, Graeme J. O’Keefe, Uwe Ackermann, Vincent Dore, Victor L. Villemagne, Christopher C. Rowe
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:EJNMMI Research
Subjects:
Radiation dosimetry
4-[ 18 F]fluorobenzyl dexetimide
Muscarinic cholinergic neuroreceptors
Positron emission tomography
Online Access:http://link.springer.com/article/10.1186/s13550-020-00641-1

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http://link.springer.com/article/10.1186/s13550-020-00641-1

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