SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPARδ signalling-mediated alternative activation of macrophages

SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPARδ signalling-mediated alternative activation of macrophages

Abstract Background The activation of tumour-associated macrophages (TAMs) contributes to the progression of hepatocellular carcinoma (HCC). SIRT4 acts as a tumour suppressor of tumour growth by regulating cell metabolism, inflammation, and anti-tumourigenesis. However, the involvement of SIRT4 in t...

Full description

Bibliographic Details
Main Authors: Zhi Li, He Li, Zhi-Bo Zhao, Wei Zhu, Pan-Pan Feng, Xi-Wen Zhu, Jian-Ping Gong
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Sirtuin 4
HCC
Tumour-associated macrophages
NF-ΚB
PPARδ/STAT3
Inflammatory cytokines
Online Access:http://link.springer.com/article/10.1186/s13046-019-1456-9

Internet

http://link.springer.com/article/10.1186/s13046-019-1456-9

Similar Items