Histone deacetylase inhibitors for cardiovascular conditions and healthy longevity

Summary: Histone deacetylase inhibitors (HDACi) regulate gene expression via epigenetic mechanisms. Accumulating evidence suggests that HDACi exert antiproliferative, antioxidant, antineoplastic, and proapoptotic effects through epigenetic mechanisms. Furthermore, HDACi also exert antithrombotic and...

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Bibliographic Details
Main Authors: João Pedro Ferreira, MD, Bertram Pitt, ProfMD, Faiez Zannad, ProfMD
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:The Lancet. Healthy Longevity
Online Access:http://www.sciencedirect.com/science/article/pii/S2666756821000611