Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model

Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model

Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under investigation, including passive immunization with anti-amyloid β (anti-Aβ) monoclonal antibodies (mAbs). Here, we investigate the therapeutic potential of a novel type of Aβ-targeting agent based on an...

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Bibliographic Details
Main Authors: Allal Boutajangout, Hanna Lindberg, Abdulaziz Awwad, Arun Paul, Rabaa Baitalmal, Ismail Almokyad, Ingmarie Höidén-Guthenberg, Elin Gunneriusson, Fredrik Y. Frejd, Torleif Härd, John Löfblom, Stefan Ståhl, Thomas Wisniewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
affibody molecule
amyloid beta (Aβ)
behavior
histology
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00064/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00064/full

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