Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

Abstract Background Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (Btk), a key signaling protein...

Full description

Bibliographic Details
Main Authors: Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll, Alex F. de Vos
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Medicine
Subjects:
Bruton’s tyrosine kinase
Ibrutinib
Pneumonia
Streptococcus pneumoniae
Sepsis
Online Access:http://link.springer.com/article/10.1186/s10020-018-0069-7

Internet

http://link.springer.com/article/10.1186/s10020-018-0069-7

Similar Items