Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein

Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein

Abnormal excitability in cortical networks has been reported in patients and animal models of Alzheimer's disease (AD), and other neurodegenerative conditions. Whether hyperexcitability is a core feature of alpha(α)-synucleinopathies, including dementia with Lewy bodies (DLB) is unclear. To ass...

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Bibliographic Details
Main Authors: Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randall, Daniel Erskine, Christopheer M. Morris, Amy K. Reeve, Gavin J. Clowry, Fiona E.N. LeBeau
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Neurobiology of Disease
Subjects:
Hippocampus
Gamma oscillations
Alpha-synuclein
Parvalbumin
Mitochondria
Burst discharges
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120305015

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http://www.sciencedirect.com/science/article/pii/S0969996120305015

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