The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis

The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis

Neutrophils are the first cells of our immune system to arrive at the site of inflammation. They release cytokines, e.g., chemokines, to attract further immune cells, but also actively start to phagocytose and kill pathogens. In the case of sepsis, this tightly regulated host defense mechanism can b...

Full description

Bibliographic Details
Main Authors: Cassiano Felippe Gonçalves-de-Albuquerque, Ina Rohwedder, Adriana Ribeiro Silva, Alessandra Silveira Ferreira, Angela R. M. Kurz, Céline Cougoule, Sarah Klapproth, Tanja Eggersmann, Johnatas D. Silva, Gisele Pena de Oliveira, Vera Luiza Capelozzi, Gabriel Gutfilen Schlesinger, Edlaine Rijo Costa, Rita de Cassia Elias Estrela Marins, Attila Mócsai, Isabelle Maridonneau-Parini, Barbara Walzog, Patricia Rieken Macedo Rocco, Markus Sperandio, Hugo Caire de Castro-Faria-Neto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
sepsis
inflammation
dasatinib
Src tyrosine kinase
leukocyte trafficking
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00901/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00901/full

Similar Items