Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistr...

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Bibliographic Details
Main Authors: Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Crystals
Subjects:
nitrofurantoin
active pharmaceutical ingredient
4-aminobenzoic acid
cocrystallization
intermolecular interaction
Raman spectroscopy
terahertz spectroscopy
Online Access:http://www.mdpi.com/2073-4352/6/12/164

Internet

http://www.mdpi.com/2073-4352/6/12/164

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