Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid
Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistr...
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doaj-7cd1e261bca64792979768d7c23f90d52020-11-24T23:03:49ZengMDPI AGCrystals2073-43522016-12-0161216410.3390/cryst6120164cryst6120164Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic AcidYong Du0Qiang Cai1Jiadan Xue2Qi Zhang3Centre for THz Research, China Jiliang University, Hangzhou 310018, ChinaCentre for THz Research, China Jiliang University, Hangzhou 310018, ChinaDepartment of Chemisty, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaCentre for THz Research, China Jiliang University, Hangzhou 310018, ChinaCocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from the molecule-level, and provides us with rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.http://www.mdpi.com/2073-4352/6/12/164nitrofurantoinactive pharmaceutical ingredient4-aminobenzoic acidcocrystallizationintermolecular interactionRaman spectroscopyterahertz spectroscopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Du Qiang Cai Jiadan Xue Qi Zhang |
spellingShingle |
Yong Du Qiang Cai Jiadan Xue Qi Zhang Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid Crystals nitrofurantoin active pharmaceutical ingredient 4-aminobenzoic acid cocrystallization intermolecular interaction Raman spectroscopy terahertz spectroscopy |
author_facet |
Yong Du Qiang Cai Jiadan Xue Qi Zhang |
author_sort |
Yong Du |
title |
Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid |
title_short |
Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid |
title_full |
Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid |
title_fullStr |
Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid |
title_full_unstemmed |
Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid |
title_sort |
raman and terahertz spectroscopic investigation of cocrystal formation involving antibiotic nitrofurantoin drug and coformer 4-aminobenzoic acid |
publisher |
MDPI AG |
series |
Crystals |
issn |
2073-4352 |
publishDate |
2016-12-01 |
description |
Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from the molecule-level, and provides us with rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields. |
topic |
nitrofurantoin active pharmaceutical ingredient 4-aminobenzoic acid cocrystallization intermolecular interaction Raman spectroscopy terahertz spectroscopy |
url |
http://www.mdpi.com/2073-4352/6/12/164 |
work_keys_str_mv |
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