Inhibitory Effect of Lomerizine, a Prophylactic Drug for Migraines, on Serotonin-Induced Contraction of the Basilar Artery

We examined the effects of lomerizine on serotonin (5-hydroxytryptamine, 5-HT)– induced contraction of the basilar artery and compared them with those of nifedipine. Although both lomerizine and nifedipine completely blocked K+-induced vasoconstriction, 5-HT–induced vasoconstriction was more strongl...

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Bibliographic Details
Main Authors: Masakazu Ishii, Shunsuke Kobayashi, Masamichi Ohkura, Ryuichi Yamamoto, Shunichi Shimizu, Yuji Kiuchi
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319311223