Extracorporeal Application of a Gel-Entrapment, Bioartificial Liver: Demonstration of Drug Metabolism and Other Biochemical Functions

Metabolic activity of a gel-entrapment, hollow fiber, bioartificial liver was evaluated in vitro and during extracorporeal hemoperfusion in an anhepatic rabbit model. The bioartificial liver contained either 100 million rat hepatocytes (n = 12), fibroblasts (n = 3), or no cells (n = 7) during hemope...

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Main Authors: Scott L. Nyberg, Ken Shirabe, Madhusudan V. Peshwa, Timothy D. Sielaff, Paul L. Crotty, Henry J. Mann, Rory P. Remmel, William D. Payne, Wei-Shou Hu, Frank B. Cerra M.D.
Format: Article
Language:English
Published: SAGE Publishing 1993-11-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979300200602