Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis

Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis

Abstract The identification of the TAR DNA-binding protein 43 (TDP-43) as the ubiquitinated cytoplasmic inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) confirmed that these two diseases share similar mechanisms, likely to be linked to the abnormal hyper...

Full description

Bibliographic Details
Main Authors: Rachel H. Tan, Yue Yang, Woojin S. Kim, Carol Dobson-Stone, John B. Kwok, Matthew C. Kiernan, Glenda M. Halliday
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43 pathology
Neuronal cytoplasmic inclusions
Morphology
Frontotemporal lobar degeneration
Amyotrophic lateral sclerosis
Online Access:http://link.springer.com/article/10.1186/s40478-017-0480-2

Internet

http://link.springer.com/article/10.1186/s40478-017-0480-2

Similar Items