Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.

Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.

Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable component to sICAM-1 levels, few genetic loci have been identified so far. To compreh...

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Bibliographic Details
Main Authors: Guillaume Paré, Paul M Ridker, Lynda Rose, Maja Barbalic, Josée Dupuis, Abbas Dehghan, Joshua C Bis, Emelia J Benjamin, Dov Shiffman, Alexander N Parker, Daniel I Chasman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3080865?pdf=render

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http://europepmc.org/articles/PMC3080865?pdf=render

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