Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease

Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease

Indoxyl sulfate (IS), a uremic toxin, causes chronic kidney disease (CKD) progression via its tubulotoxicity. After cellular uptake, IS directly induces apoptotic and necrotic cell death of tubular cells. Additionally, IS increases oxidative stress and decreases antioxidant capacity, which are assoc...

Full description

Bibliographic Details
Main Authors: Tong-Hong Cheng, Ming-Chieh Ma, Min-Tser Liao, Cai-Mei Zheng, Kuo-Cheng Lu, Chun-Hou Liao, Yi-Chou Hou, Wen-Chih Liu, Chien-Lin Lu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Toxins
Subjects:
chronic kidney disease
indoxyl sulfate
oxidative stress
renal fibrosis
tubular injury
Online Access:https://www.mdpi.com/2072-6651/12/11/684

Internet

https://www.mdpi.com/2072-6651/12/11/684

Similar Items