A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells.

A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells.

Poly(ADP-ribose) polymerase 1 (PARP1) is a key player in DNA repair, genomic stability and cell survival and it emerges as a highly relevant target for cancer therapies. To deepen our understanding of PARP biology and mechanisms of action of PARP1-targeting anti-cancer compounds, we generated a nove...

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Bibliographic Details
Main Authors: Andrea Buchfellner, Larisa Yurlova, Stefan Nüske, Armin M Scholz, Jacqueline Bogner, Benjamin Ruf, Kourosh Zolghadr, Sophie E Drexler, Guido A Drexler, Stefanie Girst, Christoph Greubel, Judith Reindl, Christian Siebenwirth, Tina Romer, Anna A Friedl, Ulrich Rothbauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4780744?pdf=render

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http://europepmc.org/articles/PMC4780744?pdf=render

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