Vascular Endothelial Growth Factor Is Regulated by the Canonical and Noncanonical Transforming Growth Factor-β Pathway in Synovial Fibroblasts Derived from Osteoarthritis Patients

Vascular Endothelial Growth Factor Is Regulated by the Canonical and Noncanonical Transforming Growth Factor-β Pathway in Synovial Fibroblasts Derived from Osteoarthritis Patients

Background. Previous studies suggest the presence of an association of vascular endothelial growth factor (VEGF) with osteoarthritis (OA) severity and pain in patients with knee OA. VEGF expression in human synovial fibroblasts (SFs) is induced by transforming growth factor-beta (TGFβ). However, the...

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Bibliographic Details
Main Authors: Shotaro Takano, Kentaro Uchida, Shintaro Shoji, Makoto Itakura, Dai Iwase, Jun Aikawa, Manabu Mukai, Hiroyuki Sekiguchi, Gen Inoue, Masashi Takaso
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2019/6959056

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http://dx.doi.org/10.1155/2019/6959056

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