Reductive stress promotes protein aggregation and impairs neurogenesis

Reductive stress promotes protein aggregation and impairs neurogenesis

Redox homeostasis regulates key cellular signaling in both physiology and pathology. While perturbations result in shifting the redox homeostasis towards oxidative stress are well documented, the influence of reductive stress (RS) in neurodegenerative diseases and its mechanisms are unknown. Here, w...

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Bibliographic Details
Main Authors: Kishore Kumar S Narasimhan, Asokan Devarajan, Goutam Karan, Sandhya Sundaram, Qin Wang, Thomas van Groen, Federica del Monte, Namakkal S. Rajasekaran
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
ER stress
Glutathione
Neurogenesis
Nrf2
Proteotoxicity
Reductive stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309447

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