Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles.

Francisella tularensis is an intracellular pathogen causing the disease tularemia, and an organism of concern to biodefence. There is no licensed vaccine available. Subunit approaches have failed to induce protection, which requires both humoral and cellular immune memory responses, and have been ha...

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Bibliographic Details
Main Authors: Adam O Whelan, Helen C Flick-Smith, Jane Homan, Zu T Shen, Zoe Carpenter, Payam Khoshkenar, Ambily Abraham, Nicola J Walker, Stuart M Levitz, Gary R Ostroff, Petra C F Oyston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6175290?pdf=render