Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

Abstract Legumain is required for maintenance of normal kidney homeostasis. However, its role in acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia-reperfusion injury (IRI) of renal arteries or folic acid in lgmn WT and lgmn KO mice. We assessed serum creatinine,...

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Bibliographic Details
Main Authors: Chuan’ai Chen, Dekun Wang, Yangyang Yu, Tianyuan Zhao, Ningning Min, Yan Wu, Lichun Kang, Yong Zhao, Lingfang Du, Mianzhi Zhang, Junbo Gong, Zhujun Zhang, Yuying Zhang, Xue Mi, Shijing Yue, Xiaoyue Tan
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03362-4

Internet

https://doi.org/10.1038/s41419-020-03362-4

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