State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose cardinal motor symptoms are attributed to dysfunction of basal ganglia circuits under conditions of low dopamine. Despite well-established physiological criteria to define basal ganglia dysfunction, correlations between indiv...

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Bibliographic Details
Main Authors: Amanda M Willard, Brian R Isett, Timothy C Whalen, Kevin J Mastro, Chris S Ki, Xiaobo Mao, Aryn H Gittis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
SNr
Parkinson's disease
6-OHDA
synuclein
physiology
Online Access:https://elifesciences.org/articles/42746

Internet

https://elifesciences.org/articles/42746

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