Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice

Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice

Abstract Background Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally expressed growth hormone, is critical in embryonic differentiation. Th...

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Bibliographic Details
Main Authors: Yi Sui, Wei Zhang, Tao Tang, Lili Gao, Ting Cao, Hongbo Zhu, Qinghua You, Bo Yu, Tao Yang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Stem Cell Research & Therapy
Subjects:
Parthenogenetic stem cells
Insulin-like growth factor-II
Differentiation
Cardiomyocytes
Acute myocardial infarction
Online Access:http://link.springer.com/article/10.1186/s13287-020-1575-4

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http://link.springer.com/article/10.1186/s13287-020-1575-4

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