Metabolic Difference of CZ48 in Human and Mouse Liver Microsomes

Metabolic Difference of CZ48 in Human and Mouse Liver Microsomes

CZ48, chemically camptothecin-20-<em>O</em>-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation and of CZ48 depletion in mouse and human liver microsomes in the presence or absence of NADPH was examine...

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Bibliographic Details
Main Authors: Beppino Giovanella, Dana Vardeman, Zhisong Cao, Albert DeJesus, Xing Liu
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:International Journal of Molecular Sciences
Subjects:
metabolism
biotransformation
cytochromeP450
UDP-glucuronosyltransferases
microsomes
CZ48
camptothecin
Online Access:http://www.mdpi.com/1422-0067/13/5/5498

Internet

http://www.mdpi.com/1422-0067/13/5/5498

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