IL-2 as a therapeutic target for the restoration of Foxp3<sup>+ </sup>regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
<p>Abstract</p> <p>Peripheral immune tolerance requires a finely controlled balance between tolerance to self-antigens and protective immunity against enteric and invading pathogens. Self-reactive T cells sometimes escape thymic clonal deletion, and can subsequently provoke autoimm...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-11-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/8/1/113 |