<i>PDX1</i> DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis

<i>PDX1</i> DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis

DNA methylation is a crucial epigenetic mechanism for gene expression regulation and cell differentiation. Furthermore, it was found to play a major role in multiple pathological processes, including cancer. In pancreatic neuroendocrine neoplasms (PNENs), epigenetic deregulation is also considered t...

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Bibliographic Details
Main Authors: Gitta Boons, Timon Vandamme, Joe Ibrahim, Geert Roeyen, Ann Driessen, Dieter Peeters, Ben Lawrence, Cristin Print, Marc Peeters, Guy Van Camp, Ken Op de Beeck
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
pancreatic neuroendocrine neoplasms
DNA methylation
PDX1
subtypes
cell-of-origin
prognosis
Online Access:https://www.mdpi.com/2072-6694/12/6/1461

Internet

https://www.mdpi.com/2072-6694/12/6/1461

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