Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing suitable targets for cancer therapy. M...

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Bibliographic Details
Main Authors: Yali Han, Wei Xie, De-Gang Song, Daniel J. Powell
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Hematology & Oncology
Subjects:
Chimeric antigen receptor
T cells
NKG2D ligands
Immunotherapy
Triple-negative breast cancer
Online Access:http://link.springer.com/article/10.1186/s13045-018-0635-z

Internet

http://link.springer.com/article/10.1186/s13045-018-0635-z

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