The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming.

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming.

Infection of host cells by Toxoplasma gondii is an active process, which is regulated by secretion of microneme (MICs) and rhoptry proteins (ROPs and RONs) from specialized organelles in the apical pole of the parasite. MIC1, MIC4 and MIC6 assemble into an adhesin complex secreted on the parasite su...

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Main Authors: Aline Sardinha-Silva, Flávia C Mendonça-Natividade, Camila F Pinzan, Carla D Lopes, Diego L Costa, Damien Jacot, Fabricio F Fernandes, André L V Zorzetto-Fernandes, Nicholas J Gay, Alan Sher, Dragana Jankovic, Dominique Soldati-Favre, Michael E Grigg, Maria Cristina Roque-Barreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007871

Internet

https://doi.org/10.1371/journal.ppat.1007871

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