Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors.

Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors.

Non-melanoma skin cancer is the most frequent type of cancer in humans. In this study we demonstrate that elevated IKKα expression in murine epidermis increases the malignancy potential of skin tumors. We describe the generation of transgenic mice overexpressing IKKα in the basal, proliferative laye...

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Main Authors: Josefa P Alameda, Rodolfo Moreno-Maldonado, M Jesús Fernández-Aceñero, Manuel Navarro, Angustias Page, José L Jorcano, Ana Bravo, Ángel Ramírez, M Llanos Casanova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3130791?pdf=render

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http://europepmc.org/articles/PMC3130791?pdf=render

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