Search for ABCB1 Modulators Among 2-Amine-5-arylideneimidazolones As a New Perspective to Overcome Cancer Multidrug Resistance

Search for ABCB1 Modulators Among 2-Amine-5-arylideneimidazolones As a New Perspective to Overcome Cancer Multidrug Resistance

Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (group...

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Bibliographic Details
Main Authors: Aneta Kaczor, Márta Nové, Annamária Kincses, Gabriella Spengler, Ewa Szymańska, Gniewomir Latacz, Jadwiga Handzlik
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
ABCB1 modulator
5-arylideneimidazolone
Dimroth rearrangement
cancer MDR
Pgp
T-lymphoma cancer cell
Online Access:https://www.mdpi.com/1420-3049/25/9/2258

Internet

https://www.mdpi.com/1420-3049/25/9/2258

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