Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells

Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells

Mesenchymal stem/stromal cells (MSCs) have the ability to secrete bioactive molecules, exerting multiple biological effects, such as tissue regeneration, reduction of inflammation, and neovascularization. The therapeutic potential of MSCs can be increased by genetic modification to overexpress cytok...

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Bibliographic Details
Main Authors: Girlaine Café Santos, Daniela Nascimento Silva, Vitor Fortuna, Brysa Mariana Silveira, Iasmim Diniz Orge, Thaís Alves de Santana, Gabriela Louise Sampaio, Bruno Diaz Paredes, Ricardo Ribeiro-dos-Santos, Milena Botelho Pereira Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem/stromal cells
genetic modification
LIF
proangiogenico factors
angiogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00778/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00778/full

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