Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele frequencies across worldwide populations. While previous studies have examined population differentiation of alleles at specific SNPs, global ethnic patterns of ensembles of disease risk alleles across human...

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Bibliographic Details
Main Authors: Rong Chen, Erik Corona, Martin Sikora, Joel T Dudley, Alex A Morgan, Andres Moreno-Estrada, Geoffrey B Nilsen, David Ruau, Stephen E Lincoln, Carlos D Bustamante, Atul J Butte
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3325177?pdf=render

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http://europepmc.org/articles/PMC3325177?pdf=render

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