Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling

Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling

Tanshinone IIA (TS IIA) and Astragaloside IV (AS IV) are natural herbal products which exert anti-inflammatory and anti-oxidant effects in order to eliminate unstable plaque in atherosclerosis. However, the combined effect of these two drugs on atherosclerotic plaque vulnerability and its molecular...

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Bibliographic Details
Main Authors: Nanding Wang, Xiaofeng Zhang, Zhen Ma, Jinghu Niu, Shihang Ma, Wang Wenjie, Jun Chen
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tanshinone IIA
Astragaloside IV
PI3K/AKT signaling
TRL4/NF-κB signaling
Atherosclerotic plaque vulnerability
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221935351X

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http://www.sciencedirect.com/science/article/pii/S075333221935351X

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