Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1

Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1

Background/Aims: Previously we have shown that activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) attenuated hyperglycemia-induced damage in podocytes, but the molecular mechanism remains unknown. Methods: Tert-butylhydroquinone (t-BHQ) and small...

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Bibliographic Details
Main Authors: Qunzi Zhang, Qiongxia Deng, Jun Zhang, JianTing Ke, Ye Zhu, Ruo wei Wen, Zengchun Ye, Hui Peng, Zhong zhen Su, Cheng Wang, Tanqi Lou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Antioxidant response element
Diabetes mellitus
Podocytes
Tert-butylhydroquinone
Sirt1
Online Access:https://www.karger.com/Article/FullText/491658

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https://www.karger.com/Article/FullText/491658

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