Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients

Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients

Background and Aims: Tacrolimus is a macrolide immunosuppressant used for prevention of allograft rejection in organ transplantation and metabolized in the liver and intestine by cytochrome P450 3A4 (CYP3A4) enzyme. A single nucleotide polymorphism (SNP) in the CYP3A4 promoter region has been identi...

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Bibliographic Details
Main Authors: Abdulkareem Albekairy, Abdulmalik Alkatheri, Shiro Fujita, Alan Hemming, Richard Howard, Alan Reed, Janet Karlix
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:The Saudi Journal of Gastroenterology
Subjects:
Cytochrome P450 3A4FNx011B
liver transplant
tacrolimus
Online Access:http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=2;spage=89;epage=95;aulast=Albekairy

Internet

http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=2;spage=89;epage=95;aulast=Albekairy

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