High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this...

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Bibliographic Details
Main Authors: Keijiro Mizukami, Akira Yabuki, Hye-Sook Chang, Mohammad Mejbah Uddin, Mohammad Mahbubur Rahman, Kazuya Kushida, Moeko Kohyama, Osamu Yamato
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2013/695918

Internet

http://dx.doi.org/10.1155/2013/695918

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