IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells

IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells

Abstract Background Family screening of a 48‐year‐old male with recently diagnosed IgG4‐related disease (IgG4‐RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons. Methods We performed gene sequencing, immune cell studies, HLA typing, and analyses of circulating cyto...

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Bibliographic Details
Main Authors: John H. Newman, Aaron Shaver, Jonathan H. Sheehan, Simon Mallal, John H. Stone, Shiv Pillai, Lisa Bastarache, Derek Riebau, Hugues Allard‐Chamard, William M. Stone, Cory Perugino, Mark Pilkinton, Scott A. Smith, Wyatt J. McDonnell, John A. Capra, Jens Meiler, Joy Cogan, Kelly Xing, Vinay S. Mahajan, Hamid Mattoo, Rizwan Hamid, John A. Phillips III, Undiagnosed Disease Network
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
cytotoxic lymphocytes
heritable
IgG4‐RD
Online Access:https://doi.org/10.1002/mgg3.686

Internet

https://doi.org/10.1002/mgg3.686

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