Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

Epileptic seizures are a common feature associated with inherited mitochondrial diseases. This study investigated the role of mitochondrial oxidative stress in epilepsy resulting from mitochondrial dysfunction using cross-bred mutant mice lacking mitochondrial manganese superoxide dismutase (MnSOD o...

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Bibliographic Details
Main Authors: Li-Ping Liang, Simon Waldbaum, Shane Rowley, Ting-Ting Huang, Brian J. Day, Manisha Patel
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Seizures
EEG
Antioxidant
Mitochondrial encephalopathy
Glutathione
3-nitrotyrosine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004001

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http://www.sciencedirect.com/science/article/pii/S0969996111004001

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