Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial

Background: Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients’ quality of life. Given excellent outcomes of human papilloma virus (HPV)-associated OPC and long-term survival of these typically young patien...

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Main Authors: Houda Bahig, Ying Yuan, Abdallah S.R. Mohamed, Kristy K. Brock, Sweet Ping Ng, Jihong Wang, Yao Ding, Kate Hutcheson, Molly McCulloch, Peter A. Balter, Stephen Y. Lai, Abrahim Al-Mamgani, Jan-Jakob Sonke, Uulke A. van der Heide, Christopher Nutting, X. Allen Li, Jared Robbins, Mussadiq Awan, Irene Karam, Katherine Newbold, Kevin Harrington, Uwe Oelfke, Shreerang Bhide, Marielle E.P. Philippens, Chris H.J. Terhaard, Andrew J. McPartlin, Pierre Blanchard, Adam S. Garden, David I. Rosenthal, Gary B. Gunn, Jack Phan, Guillaume Cazoulat, Michalis Aristophanous, Kelli K. McSpadden, John A. Garcia, Cornelis A.T. van den Berg, Cornelis P.J. Raaijmakers, Linda Kerkmeijer, Patricia Doornaert, Sanne Blinde, Steven J. Frank, Clifton D. Fuller
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Clinical and Translational Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S240563081830048X