Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Summary Neuronal ceroid lipofuscinoses, the most common fatal childhood neurodegenerative illnesses, share many features with more prevalent neurodegenerative diseases. Neuronal ceroid lipofuscinoses are caused by mutations in CLN genes. CLN6 encodes a transmembrane endoplasmic reticulum protein wit...

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Bibliographic Details
Main Authors: Katja M. Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J. Parker, Grace E. Lidgerwood, Irene Volitakis, George Ganio, Peter J. Crouch, Anthony R. White
Format: Article
Language:English
Published: The Company of Biologists 2013-05-01
Series:Biology Open
Subjects:
Neurodegeneration
Biometal homeostasis
Neuronal ceroid lipofuscinoses
CLN6
Metal transporter
Online Access:http://bio.biologists.org/content/2/6/635

Internet

http://bio.biologists.org/content/2/6/635

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