Toxic Shock Syndrome Toxin-1-Mediated Toxicity Inhibited by Neutralizing Antibodies Late in the Course of Continual in Vivo and in Vitro Exposure

Toxic Shock Syndrome Toxin-1-Mediated Toxicity Inhibited by Neutralizing Antibodies Late in the Course of Continual in Vivo and in Vitro Exposure

Toxic shock syndrome (TSS) results from the host’s overwhelming inflammatory response and cytokine storm mainly due to superantigens (SAgs). There is no effective specific therapy. Application of immunoglobulins has been shown to improve the outcome of the disease and to neutralize SAgs both in vivo...

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Bibliographic Details
Main Authors: Norbert Stich, Nina Model, Aysen Samstag, Corina S. Gruener, Hermann M. Wolf, Martha M. Eibl
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Toxins
Subjects:
toxic shock syndrome toxin-1
TNF-alpha
IL-2
neutralizing antibody
rabbit animal model
postexposure treatment
continual stimulation
Online Access:http://www.mdpi.com/2072-6651/6/6/1724

Internet

http://www.mdpi.com/2072-6651/6/6/1724

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