The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by upper and lower motoneuron death. Mutations in the gene for superoxide dismutase 1 (SOD1) cause a familial form of ALS and have been used to develop transgenic mice which overexpress human mutant SOD1 (mSOD) an...

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Bibliographic Details
Main Authors: Coral-Ann Lewis, John Manning, Fabio Rossi, Charles Krieger
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2012/803701