Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Objective: Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance. Brown adipose tissue (BAT), a therapeutic target against obesity, is an insulin target tissue sensitive to inflammation. Therefore, it is ne...

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Bibliographic Details
Main Authors: Carmen Escalona-Garrido, Patricia Vázquez, Paula Mera, Sebastián Zagmutt, Ester García-Casarrubios, Ana Montero-Pedrazuela, Fernanda Rey-Stolle, Ana Guadaño-Ferraz, Francisco J. Rupérez, Dolors Serra, Laura Herrero, Maria Jesus Obregon, Ángela M. Valverde
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
Brown adipose tissue
Inflammation
Sirtuin 1
Triiodothyronine
Insulin resistance
Uncoupling protein-1
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782030171X

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http://www.sciencedirect.com/science/article/pii/S221287782030171X

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