Neuroestradiol regulation of ventromedial hypothalamic nucleus 5′-AMP-activated protein kinase activity and counterregulatory hormone secretion in hypoglycemic male versus female rats

Neuroestradiol regulation of ventromedial hypothalamic nucleus 5′-AMP-activated protein kinase activity and counterregulatory hormone secretion in hypoglycemic male versus female rats

Hypoglycemia activates the ultra-sensitive energy gauge 5′-AMP-activated protein kinase (AMPK) in ventromedial hypothalamic nucleus (VMN) gluco-regulatory neurons. The VMN is exemplified by high levels of expression of the enzyme aromatase, which converts testosterone to estradiol. This study examin...

Full description

Bibliographic Details
Main Authors: MD Main Uddin, Karen P Briski
Format: Article
Language:English
Published: AIMS Press 2021-01-01
Series:AIMS Neuroscience
Subjects:
letrozole
aromatase
insulin-induced hypoglycemia
ventromedial hypothalamic nucleus
ampk
sex differences
Online Access:http://www.aimspress.com/article/doi/10.3934/Neuroscience.2021006?viewType=HTML

Internet

http://www.aimspress.com/article/doi/10.3934/Neuroscience.2021006?viewType=HTML

Similar Items